Glycosylation is now well recognized as a key quality attribute for many biologics. Siamed Technologies offer innovative services to control glycan heterogeneity during product and process development. They aim at selecting the best profile for the product to improve biological performances and meet regulatory compliance:
• Analytical technologies provide a customizable screening which can govern and control product heterogeneity at all steps. Glycotests greatly facilitate decision making before entering further analytical and biological characterization. Glycomonitoring derisks and accelerates product development.
• Glycoengineering CHO cells is requested to produce better and safer biologics. Efficient 6-sialylation physiologically prevents immune recognition of the product and impairs hepatic clearance of a protein drug.
• In Diagnostics, producing calibrators truly mimicking the diseased marker is often challenging. We offer consultancy to select the best expression system and epitope mapping to readily construct the
most performant sandwich assays.
